ERG gene region 21q22
FFPE FISH for ERG
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Fluorescence In Situ Hybridization (FISH)
This test detects rearrangements involving the ERG gene region (21q22) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using a dual-color break-apart probe (Empire Genomics) to qualitatively assess for the presence of ERG rearrangements that are associated with a subset of prostatic adenocarcinoma. Testing for ERG gene rearrangement may aid in: 1. Diagnosis and classification of a subset of prostatic adenocarcinoma 2. Diagnosis and classification of a subset of neuroendocrine prostate cancer 3. Confirmation of presence or absence of ERG gene rearrangement in prostatic adenocarcinoma cases with equivocal ERG immunohistochemical expression. 4. Differential diagnosis of poorly differentiated prostate cancer versus poorly differentiated urothelial cancer 5. Diagnosis of ERG positive metastatic prostatic adenocarcinoma 6. Diagnosis of ERG positive prostatic adenocarcinoma with low or equivocal ERG immunohistochemical expression (for example, treated prostate cancer).
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Submit a formalin-fixed, paraffin block of the prostate cancer tissue (with matched benign prostate tissue if available); store at room temperature. Please complete a MiChart test request and submit it with the specimen. A Cytogenetics Laboratory Requisition is available online at: http://www.pathology.med.umich.edu/handbook/Tables/UM_REQ_CYTOGENETICS…. Specify "Other" in the FISH Oncology Probes section, write in ERG and submit with the specimen.
Submit a formalin-fixed, paraffin block of the tumor tissue (with matched benign prostate tissue if available); store at room temperature.