Test Overview
Test Usage

Investigating new onset cryptogenic epilepsy with incomplete seizure control and duration of less than 2 years
Investigating new onset cryptogenic epilepsy plus 1 or more of the following accompaniments:
-Psychiatric accompaniments (psychosis, hallucinations)
-Movement disorder (myoclonus, tremor, dyskinesias)
-Cognitive impairment/encephalopathy
-Autoimmune stigmata (personal history or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, premature graying of hair, myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus, idiopathic adrenocortical insufficiency), or multiple sclerosis
-History of cancer
-Smoking history (20+ pack years) or other cancer risk factors
-Investigating seizures occurring within the context of a subacute multifocal neurological disorder without obvious cause, especially in a patient with past or family history of cancer
-A rising autoantibody titer in a previously seropositive patient suggests cancer recurrence

Reference Range *

Interpretive report provided.

Test Details
Days Set Up
Monday - Sunday
Analytic Time

11 - 14 days

Soft Order Code
Reference Laboratory
Mayo EPS2
Special Testing
Specimen Requirements
Collection Instructions

Collect blood in SST or red top tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Normal Volume
4 mL serum
Minimum Volume
2.5 mL serum
Additional Information

Test includes Anti-Neuronal Nuclear Antibody Type 1, Anti-Neuronal Nuclear Antibody Type 2, Anti-Neuronal Nuclear Antibody Type 3, Purkinje Cell Cytoplasmic Antibody Type 2, Purkinje Cell Cytoplasmic Antibody Type Tr, Amphiphysin Antibody, CRMP-5-IgG, NMDA-R Ab CBA, Neuronal (V-G) K+ Channel Antibody, LGI1 IgG, CASPR2 IgG, GAD65 Antibody, GABA-B-R Ab CBA, AMPA-R Ab CBA, Anti-Glial Nuclear Antibody Type 1, Calcium Channel Binding Antibody N-Type, Calcium Channel Binding Antibody P/Q Type, ACh Receptor (Muscle) Binding Antibody, and AChR Ganglionic Neuronal Antibody.
The following tests are reflexed at an additional charge when indicated: Purkinje Cell Cytoplasmic Antibody Type 1 (PCABP), Paraneoplastic Autoantibody Western Blot (WBLOT), CRMP-5-IgG Western Blot (C5BLO), Amphiphysin Antibody Western Blot (AMPWB), NMO/AQP4-IgG FACS (NMOFS), NMO/AQP4-IgG FACS Titer (NMOTS), NMDA-R Ab IF Titer (NMDIS), AMPA-R Ab IF Titer (AMPIS), and/or GABA-B-R Ab IF Titer (GABIS). By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated. Test sent to Mayo Medical Laboratories.

CPT Code
83519 x 5, 86255 x 13, 86341
Fee Code
AA272 x5, AA273, AA274 x13
Reflex CPT
PCABP 86255, WBLOT 84182, C5BLO 84182, AMPWB 84182, NMOFS 86255, NMOTS 86256, NMDIS 86256, AMPIS 86256, GABIS 86256
Reflex Fee Code
PCABP AA335, WBLOT 36141, C5BLO 36140, AMPWB 38138, NMOFS 38139, NMOTS AA255, NMDIS AA194, AMPIS AA196, GABIS AA198
NY State Approved