Investigating new onset cryptogenic epilepsy with incomplete seizure control and duration of less than 2 years
Investigating new onset cryptogenic epilepsy plus 1 or more of the following accompaniments:
-Psychiatric accompaniments (psychosis, hallucinations)
-Movement disorder (myoclonus, tremor, dyskinesias)
-Autoimmune stigmata (personal history or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, premature graying of hair, myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus, idiopathic adrenocortical insufficiency), or multiple sclerosis
-History of cancer
-Smoking history (20+ pack years) or other cancer risk factors
-Investigating seizures occurring within the context of a subacute multifocal neurological disorder without obvious cause, especially in a patient with past or family history of cancer
-A rising autoantibody titer in a previously seropositive patient suggests cancer recurrence
Interpretive report provided.
7 - 11 days
Test includes Anti-Neuronal Nuclear Antibody Type 1, Anti-Neuronal Nuclear Antibody Type 2, Anti-Neuronal Nuclear Antibody Type 3, Purkinje Cell Cytoplasmic Antibody Type 2, Purkinje Cell Cytoplasmic Antibody Type Tr, Amphiphysin Antibody, CRMP-5-IgG, NMDA-R Ab CBA, Neuronal (V-G) K+ Channel Antibody, LGI1 IgG, CASPR2 IgG, GAD65 Antibody, GABA-B-R Ab CBA, AMPA-R Ab CBA, Anti-Glial Nuclear Antibody Type 1, Calcium Channel Binding Antibody N-Type, Calcium Channel Binding Antibody P/Q Type, ACh Receptor (Muscle) Binding Antibody, and AChR Ganglionic Neuronal Antibody.
The following tests are reflexed at an additional charge when indicated: Purkinje Cell Cytoplasmic Antibody Type 1 (PCABP), Paraneoplastic Autoantibody Western Blot (WBLOT), CRMP-5-IgG Western Blot (C5BLO), Amphiphysin Antibody Western Blot (AMPWB), NMO/AQP4-IgG FACS (NMOFS), NMO/AQP4-IgG FACS Titer (NMOTS), NMDA-R Ab IF Titer (NMDIS), AMPA-R Ab IF Titer (AMPIS), and/or GABA-B-R Ab IF Titer (GABIS). By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated. Test sent to Mayo Medical Laboratories.