Days Set Up
Daily, 24 hours
Analytic Time

2 hours

MiChart Code
Digoxin Level
Soft Order Code

Test Updated:



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Test Overview

Test Methodology

Kinetic Immunoassay (KIMS)

Test Usage

Diagnosis of digoxin toxicity, monitor therapeutic drug level.

Reference Range

0.5 - 1.5 ng/mL. Note that in the setting of chronic heart failure, retrospective analysis of data from a randomized clinical trial revealed the following associations between serum digoxin concentrations and all-cause mortality: 0.5 to 0.8 ng/mL, lower risk than placebo; 0.9 to 1.1 ng/mL, similar risk to placebo; 1.2 ng/mL and above, higher risk than placebo. Critical Value: >2.0 ng/mL.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Collect blood in a red top tube. Blood specimen should be drawn 6-8 hours after the administration of the last dose. If I.V. is being given, draw sample 30-60 minutes after termination of I.V.. Cause for Rejection: Patient digitalized with drug other than digoxin. Digoxin levels will be falsely elevated with digitalis, digibind, and digitoxin therapy.

Collection Offsite

Collect blood in a red top tube. Centrifuge, aliquot serum into a plastic vial, and refrigerate. Blood specimen should be drawn at least 8 hours after the administration of the last dose (falsely elevated results may occur if blood is drawn less than eight hours after last dose).

Red Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.25 mL serum

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.