Investigating new onset dementia and cognitive impairment plus 1 or more of the following:
-Rapid onset and progression
-Fluctuating course
-Psychiatric accompaniments (psychosis, hallucinations)
-Movement disorder (myoclonus, tremor, dyskinesias)
-Headache
-Autoimmune stigmata (personal history or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus)
-Smoking history (20+ pack years) or other cancer risk factors
-History of cancer
-Inflammatory cerebral spinal fluid
-Neuroimaging findings atypical for degenerative etiology