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Interphase Fluorescence In Situ Hybridization (FISH)
Rearrangements of PDGFRA, PDGFRB, FGFR1 and PCM1-JAK2 are found in a rare group of stem cell myeloid and lymphoid neoplasms that have in common the presence of eosinophilia and the involvement of genes that code for a tyrosine kinase. This FISH panel aids in diagnosis and classification of hematopoietic neoplasms presenting with prominent eosinophilia. It includes probes that target the PDGFRA (4q12 tricolor rearrangement probe), PDGFRB (5q33.1 break apart probe), FGFR1 (8p11 break apart probe), and JAK2 (9p24 break apart probe) loci. Detection of these rearrangements will help to properly diagnose and treat these patients. Furthermore, patients with activated tyrosine kinases are good candidates for tyrosine kinase inhibitors.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Collect specimen in a sterile syringe rinsed with sodium heparin or a green top Vacutainer® (sodium heparin) tube. Invert several times to prevent clotting. Send at room temperature as soon as possible. Do not allow specimen to overheat or freeze. Please complete a MiChart test request and submit it with the specimen. A Cytogenetics Laboratory Requisition is available online at: http://www.pathology.med.umich.edu/handbook/Tables/UM_REQ_CYTOGENETICS…. Eosinophilia FISH panel testing may be performed as a "stand alone" test or included with Chromosome Analysis.
Specimen transport should be arranged so that the specimen is received by MLabs the same day it is collected. Call for a STAT courier if necessary. Collect specimen in a green top (sodium heparin) tube. Invert the tube several times to prevent clotting. Send at room temperature as soon as possible. Do not allow specimen to overheat or freeze. Clotted samples or those that are greater than 24 hours old are suboptimal. Eosinophilia FISH panel testing may be performed as a "stand alone" test or included with Chromosome Analysis.