ETV6/RUNX1 (TEL/AML1) t(12;21)
FISH Oncology Probes
CHIC2 deletion, FISH Probe
PDGFRA Translocation Detection by FISH
GENERIC CYTOGENETICS TEST
FISH for Neoplasia
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Fluorescence In Situ Hybridization (FISH)
Oncology probes are useful for assisting in diagnosis and classification of malignant hematologic disorders and certain solid tumors, evaluating prognosis and monitoring treatment. For example, identification and monitoring of the BCR/ABL fusion gene in patients with chronic myelogenous leukemia or acute lymphocytic leukemia, for new diagnosis of APL using a probe for PML/RARA, and for detecting the cryptic t(12;21) in pediatric ALL. See also separate test listing for Cytogenetics, FISH Panel for CLL.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
FISH testing is performed as an adjunct to Chromosome Analysis when appropriate using the specimen submitted for Chromosome Analysis, unless otherwise approved by the Cytogenetics Laboratory Director. Please contact the Cytogenetics Laboratory prior to collecting specimen to request "stand alone" FISH testing, except for follow-up studies of CML patients on Gleevec. See "Cytogenetics, Chromosome Analysis, Bone Marrow" or "Cytogenetics, Chromosome Analysis, Blood for Malignancy" for specimen collection and handling requirements. Please complete a MiChart test request and submit it with the specimen. A Cytogenetics Laboratory Requisition is available online at: http://www.pathology.med.umich.edu/handbook/Tables/UM_REQ_CYTOGENETICS….
FISH testing is performed as an adjunct to Chromosome Analysis when appropriate using the specimen submitted for Chromosome Analysis, unless otherwise approved by the Cytogenetics Laboratory Director. Specimen transport should be arranged so that the specimen is received by MLabs the same day it is collected. Call for a STAT courier if necessary. See "Cytogenetics, Chromosome Analysis, Bone Marrow" or "Cytogenetics, Chromosome Analysis, Blood for Malignancy" for specimen collection and handling requirements.