Days Set Up
Monday - Friday, 8:00am - 4:00pm
Analytic Time

3 weeks

MiChart Code
Cytogenetics, Chromosome Analysis/Karyotype, Products of Conception
Soft Order Code
CGNPC

Test Updated:

Synonyms

CGLABEL
GENERIC CYTOGENETICS TEST
CGNPC
Cytogenetics, Fetal Tissue
Karyotype, Tissue
Chromosome Analysis, Placenta
Chromosome Analysis, Products of Conception (POC)

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

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Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

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Test Overview

Test Methodology

Cell culture and chromosome analysis. Fluorescence In Situ Hybridization (FISH) when indicated.

Test Usage

Generally, products of conception are submitted for cytogenetic analysis if the couple has had 2 or more previous miscarriages, or if fetal abnormalities were observed. Approximately 50% of first trimester abortuses and 6% of later abortuses are chromosomally abnormal, frequently due to trisomy or monosomy following an abnormal meiotic division (nondisjunction). Chorionic villi (up to 12 weeks gestation) or fetal parts should be submitted for analysis; the Cytogenetics laboratory can isolate this material if an entire specimen or uterine contents is submitted un-fixed.

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Place POC in sterile container with Chromosome Media. Please complete a MiChart test request and submit it with the specimen. A Cytogenetics Laboratory Requisition is available online at: http://www.pathology.med.umich.edu/handbook/Tables/UM_REQ_CYTOGENETICS….

Collection Offsite

Store cytogenetic transport media frozen until ready for use. If possible, specimen transport should be arranged so that the specimen is received by MLabs the same day it is collected. Call for a STAT courier or send via Priority Overnight delivery. Place POC specimen in a sterile screw top container containing cytogenetic transport media. If a kit is not available, use a sterile urine cup and sterile RPMI, sterile Hank’s Solution, or sterile saline for specimen transport. If using saline do not submerge the specimen, use just enough to keep it moist. Do not send the specimen dry. DO NOT ADD FORMALIN OR FREEZE. POCs often contain large numbers of bacteria so refrigerate if specimen must be stored overnight. Transport with a cold pack or at room temperature. Do not allow specimen to freeze. Submit the POC sample along with a completed MLabs Constitutional Cytogenetics Requisition form: http://mlabs.umich.edu/files/pdfs/REQ-Cytogenetics_REFR.pdf.

Minimum Volume
 

Billing Information

CPT Code
88262 Chromosome Analysis, 88233 Tissue Culture
Pro Fee Code
 
LOINC
 

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.