Days Set Up
Monday - Friday, 8:00am - 4:00pm. Call the laboratory at 734-763-5805 for additional information.
Analytic Time

7-10 days

MiChart Code
Cytogenetics, Chromosome Analysis, Blood for Malignancy
Soft Order Code

Test Updated:


Chromosome Analysis, Blood for Malignancy
Karyotype, Malignancy
Chromosome Analysis for Hematologic Disorders, Blood

Looking to order a test?

We’ve provided helpful links to make ordering easy.

Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

Visit our provider FAQ and learn about common questions to ordering tests.

Test Overview

Test Methodology

Short term cell culture and chromosome analysis, cultures with and without mitogens. Fluorescence In Situ Hybridization (FISH) when indicated. Samples with an indication of mature B-cell lymphoma including, but not limited to, CLL/SLL, follicular lymphoma, mantle cell lymphoma and marginal zone lymphoma, will have an extra culture inoculated with CpG-oligonucleotide (CpG) and Interleukin-2 (IL2). Similarly, samples with an indication of mature T-cell lymphoma/leukemia (T-PLL, AITCL, ALCL) will have an extra culture inoculated with Phytohemagglutinin (PHA). A minimum of 10 metaphase cells are analyzed from mitogen stimulated cultures, in addition to the standard 20 metaphase cells analyzed from the unstimulated cultures.

Test Usage

Rule out acquired chromosomal abnormalities associated with hematologic disease. If the patient has at least 10% blasts (or a combination of blasts, promyelocytes and myelocytes totaling 10%) a peripheral blood sample may be useful, however, a bone marrow sample is preferred.

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Collect specimen in a green top (sodium heparin) tube. Specimen should be drawn and sent during laboratory hours. Invert the tube several times to prevent coagulation. Please complete a MiChart test request and submit it with the specimen. A Cytogenetics Laboratory Requisition is available online at:….

Collection Offsite

Specimen transport should be arranged so that the specimen is received by MLabs the same day it is collected. Collect specimen in a green top (sodium heparin) tube. Invert the tube several times to prevent clotting. Send the specimen at room temperature as soon as possible. DO NOT CENTRIFUGE. Clotted samples, samples containing <5 million dividing cells, and samples that are greater than 24 hours old are considered suboptimal.

Normal Volume
5-10 mL whole blood
Minimum Volume
2 mL whole blood; additional specimen may be required for patients with extremely low white cell counts.

Billing Information

CPT Code
88262, 88237, 88280x3, 88285
Pro Fee Code

Have More Questions?

Explore our helpful billing resources:

Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.