Array CGH (aCGH), Tumor
Microarray CGH, Tumor
Chromosomal Microarray Analysis, Tumor
Array for Neoplasia, Tumor
Cytogenomic Microarray, Neoplasia
Cancer Cytogenomic Microarray, Tumor
SNP Array, Tumor
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This Cancer Cytogenomic Array assay is performed using the Affymetrix Cytoscan HD platform. This array contains more than 2.6 million copy number markers, including 750,000 SNPs, with a median spacing of 0.88 kb within genes. Patient DNA is isolated, amplified, enzymatically fragmented, and hybridized to oligonucleotide probes. The array is washed, scanned, and the results are analyzed and interpreted using Affymetrix Chromosome Analysis Suite software (ChAS).
Cancer Cytogenomic Array assay detects DNA copy number gains (including amplification) and losses as well as regions of copy neutral loss of heterozygosity (CN-LOH) by SNP analysis. This assay is particularly useful for malignant conditions with a low mitotic index and when limited material is available for standard cytogenetic analysis. At least 30% malignant cells must be present in the sample submitted for Cancer Cytogenomic Array assay.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Collect tumor specimen using aseptic technique. Place in Chromosome Media in a Nalgene cryogenic vial, available from Specimen Processing. Send at room temperature as soon as possible (within 24 hours of collection). Do not allow specimen to overheat or freeze. Small samples with insufficient amount of DNA or necrotic samples with greatly degraded DNA are not acceptable. Please complete a MiChart test request and submit it with the specimen. A Cytogenetics Laboratory Requisition is available online at: http://www.pathology.med.umich.edu/handbook/Tables/UM_REQ_CYTOGENETICS….
Specimen transport should be arranged so that the specimen is received by MLabs the same day it is collected. Call for a STAT courier if necessary. Collect tumor specimen using aseptic technique. Place tissue in Chromosome Media in a Nalgene cryogenic vial, available from MLabs. Specimen must be shipped at at room temperature and received by the laboratory within 24 hours of collection. Do not allow specimen to overheat or freeze. Alternatively, fresh specimen can be frozen at less than or equal to -20 degrees C and shippped on dry ice by overnight courier. Small samples with insufficient amount of DNA or necrotic samples with greatly degraded DNA are not acceptable. Most insurance carriers require prior authorization for payment. Testing will not begin until insurance prior authorization is received, it is confirmed that prior authorization is not required, or the patient has agreed to pay out of pocket. A completed Michigan Medicine Request and Consent for Genetic Testing form is required and is available by calling 800-862-7284 or online: https://mlabs.umich.edu/sites/default/files/2020-01/file/pci-mmgl_infor….