Days Set Up
Monday - Friday
Analytic Time

72 hours

MiChart Code
Cryo Follow-up Monoclonal Gammopathy
Soft Order Code

Test Updated:


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All specimens should be accompanied by a requisition.

Submitting Specimens

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MLabs provides all the supplies necessary for the collection of specimens.

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Test Overview

Test Methodology

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Test Usage

To accurately follow known cryoglobulin monoclonal gammopathy patients. To follow, identify and type monoclonal immunoglobulins for heavy and light chain specificity. Monoclonal gammopathy evaluation (MGE) is essential when clinical, hematologic, or pathologic findings indicate: multiple myeloma, Waldenstrom;s, heavy chain disease, amyloidosis, or immunoglobulin deposition disease. MGE is also essential in the presence of abnormal bands on serum protein electrophoresis (TPE), in cryoglobulins, in Bence Jones proteinuria, in pyroglobulins, and in hyperviscosity syndrome.
Test includes serum protein electrophoresis, total protein, immunoglobulin quantitation (IgG, IgA, IgM), and serum free light chains.

Reference Range

Pathologist interpretation of results provided. See individual test reference ranges.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Obtain a thermos with a 37 degrees C warm pack from the laboratory BEFORE drawing the specimen. Thermos may be obtained from Chemical Pathology at 936-6702, Monday - Friday 7:30am - 3:30pm. Contact Specimen Processing at 936-6727 at other times. Specimens will not be accepted between 3:30pm Friday and 7:30am Monday. IMMEDIATELY after drawing place the specimen into the thermos. Specimen must be returned IMMEDIATELY in the warm thermos to Specimen Processing.

Collection Offsite

Whole blood must be maintained at 37 degrees C +/- 2 degrees from the time it is collected until serum is separated from the cells. Collect blood in pre-warmed red top tube (serum separator is unacceptable). Immediately place the specimen into a 37 degrees +/- 2 C incubator or water bath. Leave at 37 degrees C until the clot retracts, remove serum from clot, centrifuge at room temperature, and aliquot cell free serum into plastic aliquot tube. Please note on the specimen label that the specimen was processed at 37 degrees C. Keep serum at room temperature until delivered to MLabs. If specimen processing equipment is not available, the patient should have the specimen collected at a Michigan Medicine Taubman Center Blood Draw Station.

Red Top Tube
Normal Volume
2 mL serum
Minimum Volume
1 mL serum

Billing Information

CPT Code
84165, 82784 x3, 83883 x2
Pro Fee Code
84165 TPE
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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.