Days Set Up
Monday - Friday
Analytic Time

Preliminary results are reported in 48 hours; final results are reported in 7 days.

MiChart Code
Cryoglobulin (CRYO) **Onsite drawstations only - Do Not Draw Offsite**
Soft Order Code

Test Updated:



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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

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MLabs provides all the supplies necessary for the collection of specimens.

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Test Overview

Test Methodology

Incubation of serum at 4 degrees C and 37 degrees C, positive cryoglobulins redissolved and further characterized. Interpretation of positive results is made by a pathologist. Cryocrit run on positive cryoglobulins to determine what percent of the serum is cryoglobulin.

Test Usage

Cryoglobulin detection. Cryoglobulins may be present in multiple myeloma, Waldenstrom's macroglobulinemia, lymphocytic leukemia, autoimmune diseases and hepatitis C infection.

Reference Range


* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Obtain a Thermos with a 37 degrees C warm pack from the laboratory BEFORE drawing specimen. Thermos may be obtained from Chemical Pathology at 936-6702, Monday - Friday, 7:30am - 3:30pm. Contact Specimen Processing at 936-6727 at other times. Specimens will not be accepted between 3:30pm Friday and 7:30am Monday. IMMEDIATELY after drawing place specimen into Thermos. Specimen must be returned IMMEDIATELY in the warm Thermos to Specimen Processing. Time received and internal temperature of Thermos at receipt are to be record on requisition.

Collection Offsite

Whole blood must be maintained at 37 degrees C +/- 2 degrees C from the time it is collected until serum is separated from the cells. Collect blood into prewarmed red top tubes (serum separator tube is unacceptable). Within one minute, specimen must be placed into a 37 degrees C +/- 2 degrees C incubator or waterbath. Leave specimen at 37 degrees C until clot retracts; blood may be left at 37 degrees C up to 24 hours. After the clot retracts, remove serum from clot, centrifuge at room temperature, and aliquot 5 mL cell free serum into two aliquot tubes (2.5 mL each). Please note on requisition or as a footnote in the computer that the specimen was processed at 37 degrees C. Keep serum specimen at ambient (room) temperature until delivered to MLabs. If specimen processing equipment is not available, the patient should have the specimen collected at a University of Michigan Taubman Center Blood Drawing station.

Red Top Tube
Normal Volume
5 mL serum (Note: requires collection of approx. 15 mL whole blood)
Minimum Volume
4 mL serum (Note: requires collection of approx. 15 mL whole blood)

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.