Days Set Up
Monday, Thursday
Analytic Time

8 hours

MiChart Code
Complement, Total (CH50)
Soft Order Code

Test Updated:


CAE Total Complement
Functional Complement Assay
Total Active Complement
Total Hemolytic Complement

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

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Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

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Test Overview

Test Methodology

Enzyme Immunoassay

Test Usage

Follow lupus patient's response to therapy; screen for genetic complement component deficiency. Detection of deficiencies and decreased levels of serum complement as seen in renal disease (acute glomerulonephritis, membranoproliferative glomerulonephritis, renal allograft rejection), collagen disease (active systemic lupus erythematosus (SLE), 10% of patients with rheumatoid arthritis (RA), hemolytic anemia (paroxysmal cold hemoglobinuria), hypersensitivity and autoimmune diseases (acute serum sickness, acute vasculitis) as well as subacute bacterial endocarditis, mixed cryoglobulinemia, and advanced hepatic cirrhosis.

Reference Range

41 - 95 U/mL

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

All Michigan Medicine Collection: Collect specimen in a red top or SST tube. Place tube on ice immediately and transport on ice to Specimen Processing. For Health Center Sites, allow to clot at room temperature for 30 minutes, not more than 60 minutes, centrifuge, and aliquot serum and freeze. Cause for Rejection: Specimen off ice longer than 1 hour, serum not separated from red cells within 60 minutes of collection, or serum aliquot refrigerated longer than 48 hours.

Collection Offsite

MLAB Collection: Collect specimen in a red top or SST tube. Allow the specimen to clot at room temperature for 30 to 60 minutes (65 minutes maximum). Centrifuge and aliquot serum into a plastic vial. Freeze immediately.

Red Top Tube
Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.2 mL serum

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.