8 - 48 hours
Test Updated:
Plasmacytoma
Plasma Cell Dyscrasia
Immunophenotypic Plasma Cell Panel
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Test Overview
Direct immunofluorescence using flow cytometric techniques.
Confirmation of diagnosis and immunophenotype of plasma cell disorders. See http://www.pathology.med.umich.edu/handbook/Tables/Flow_Cytometry_Panel… for all Flow Cytometry Panels.
Pathologist interpretation of results provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Specimen Requirements
The following information is required on a Hematopathology Consult requisition:
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Relevant clinical history
Clinical or morphological findings and suspicions
Specimen source
Date and time of collection
Phone number and after hours pager number for ordering physician
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[bold]BLOOD:[/bold]
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Collect in a 7-10 ml green sodium heparin Vacutainer® tube and transport at room temperature within 12 hours of collection
Include a copy of the patient's concurrently drawn White Blood Cell and Platelet counts, peripheral blood differential and an unstained peripheral blood smear, OR, concurrently collect a lavender EDTA Vacutainer® tube for a CBCD to be performed upon receipt of the specimen.
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[bold]BONE MARROW ASPIRATE:[/bold]
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Add 1 - 2 ml of first pull bone marrow aspirate to a green top sodium heparin Vacutainer® tube. Send intact specimen at room temperature within 12 hours of collection.
Include 4 unstained aspirate smears
Include an unstained peripheral blood smear
Include a copy of the patient's most recent White Blood Cell and platelet counts, and peripheral blood differential, OR, concurrently collect a lavender EDTA Vacutainer® tube for a CBCD to be performed upon receipt of the specimen.
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[bold]BODY FLUID and CSF:[/bold]
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Add body fluid (e.g., CSF, pleural, peritoneal) to a clean, leak proof sterile container and send at room temperature within 12 hours of collection.
Include a a copy of the body fluid cell count and differential.
An original cytospin preparation (preferably unstained) should be included when possible with CSF specimens for correlative morphological evaluation.
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[bold]BONE MARROW CORE BIOPSY AND FNA:[/bold]
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Submerge in RPMI tissue culture medium (for optimal cell viability) or sterile saline and transport at room temperature within 12 hours of collection.
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[bold]FRESH TISSUE:[/bold]
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Mince and submerge in RPMI tissue culture medium (for optimal cell viability) or sterile saline, refrigerate, and transport refrigerated within 12 hours of collection.
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[bold]BLOOD:[/bold] 7-10 ml
[bold]BONE MARROW ASPIRATE:[/bold] 1-2 ml
[bold]BODY FLUIDS:[/bold] 20-50 ml
[bold]CSF:[/bold] 5-10 ml
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[bold]BLOOD:[/bold] 1 ml
[bold]BONE MARROW ASPIRATE:[/bold] 1 ml
[bold]BODY FLUIDS:[/bold] 5 ml*
[bold]CSF:[/bold] 1 ml*
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* The volume of Body Fluids and CSF required is dependent on the cellularity of the specimen.