Test Overview
Test Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)

Test Usage

IgA cardiolipin antibody is occasionally detected in SLE and SLE-like patients and appears to be most commonly associated with cerebrovascular thrombosis.

Reference Range *

<15 APL (negative), 15.0 – 39.9 APL (weakly positive), 40.0 – 79.9 APL (positive), > or =80.0 APL (strongly positive). APL refers to IgA Phospholipid Units. One APL unitis 1 microgram of IgA antibody.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

The immunoassay for phospholipid antibodies does not distinguish between autoantibodies and antibodies produced in response to infectious agents or as epiphenomena following thrombosis. For this reason, a single positive test result is not sufficient to meet accepted serologic criteria for the diagnosis of APS.

Test Details
Days Set Up
Monday, Wednesday, Friday
Analytic Time

4 - 6 days

Soft Order Code
ACLIP
Synonyms
  • Phospholipid (Cardiolipin) Antibody IgA
  • IgA Phospholipid Antibody (APL)
  • aCL Antibody
  • ACLIP
Laboratory
Sendout
Reference Laboratory
Mayo ACLIP (86179)
Section
Special Testing
Specimen Requirements
Collection

Collect specimen in an SST or red top tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.4 mL serum
Storage Temperature
Refrigerated (preferred): 21 days Frozen: 21 days.
Additional Information

Test sent to Mayo Medical Laboratories.

Billing
CPT Code
86147
LOINC
17459-9
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