Days Set Up
Mondays and Thursdays
Analytic Time

1-4 hours

MiChart Code
Soft Order Code

Test Updated:


Buprenorphine Glucuronide

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

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MLabs provides all the supplies necessary for the collection of specimens.

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Test Overview

Test Methodology

UPLC-MS/MS (Ultra pressure liquid chromatography tandem mass spectrometry)

Test Usage

Monitoring compliance with buprenorphine therapy and identification of specimen adulteration intended to mimic compliance with prescribed buprenorphine.

Reference Range


Positive results for buprenorphine and/or metabolites concentration are reported quantitatively. The concentration value must be greater than or equal to the cutoff to be reported as positive.

Cutoff Concentration:
Buprenorphine: 5 ng/mL
Norbuprenorphine: 5 ng/mL
Buprenorphine Glucuronide: 5 ng/mL
Norbuprenorphine Glucuronide: 5 ng/mL

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Collect random urine specimen in clean plastic container.

Collection Offsite

Collect random urine specimen in clean plastic container.

Normal Volume
3 mL random urine
Minimum Volume
1 mL random urine

Billing Information

CPT Code
80348 (Alt code: G0480)
Pro Fee Code
49752-9, 49751-1

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.