Days Set Up
Daily, 24 hours
Analytic Time

2 hours

MiChart Code
Bivalirudin Level, Anit-IIa Inhibitor Assay
Soft Order Code
BIVAL

Test Updated:

Synonyms
 

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Test Overview

Test Methodology

Anti-IIa clottable assay

Test Usage

Used for monitoring Bivalirudin therapy.

Reference Range

The concentration in a normal individual is zero. Bivalirudin exhibits linear pharmacokinetics following IV administration to patients undergoing percutaneous transluminal coronary angioplasty(PTCA). In these patients, a mean steady state Bivalirudin concentration of 12.3 +/- 1.7 mcg/mL is achieved following a IV bolus of 1 mg/kg, and a 4 - hour 2.5 mg/kg/hr IV infusion.

For anticoagulation outside of PTCA, the dosing is lower. For ECMO, it is usually started at 0.1 - 0.2 mg/kg/hr up to 0.5 mg/kg/hr with levels of 1.23 - 2.46 mcg/mL.

This test was developed and its performance characteristics were determined by Michigan Medicine. It has not been cleared or approved by the FDA. The laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes. It should not be regarded as investigational or for research.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

Collect specimen in a blue top (citrate 3.2%) tube. Mix by inversion. Specimen should arrive at lab within 4 hours of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into a plastic vial, and freeze the specimen within 4 hours of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.

Blue Top Tube
Normal Volume
Full 2.7mL tube or 1mL plasma aliquot
Minimum Volume
Full 1.8mL tube or 1mL plasma aliquot

Billing Information

CPT Code
85130
Pro Fee Code
 
LOINC
 

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.