Days Set Up
Monday - Friday
Analytic Time

8 hours

MiChart Code
Beta 2 Microglobulin
Soft Order Code

Test Updated:



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Test Overview

Test Methodology


Test Usage

Beta-2-microglobulin (beta-2-m) is expressed on the surface of nucleated cells as a subunit of class I major histocompatibility complex molecules. Uncomplexed beta-2-m (11,800 daltons) is normally shed into the circulation in low concentration, freely filtered across glomerular basement membrane, and largely reabsorbed by proximal tubular epithelium. Increased serum/plasma concentrations of beta-2-m are frequently seen under conditions of increased cell turn over - including malignant neoplasms (especially B lymphocytes), inflammation, and some infections. Older studies of patients with multiple myeloma, before treatment, correlated high concentrations of beta-2-m with worse prognosis than observed in patients with myeloma and lower concentrations of beta-2-m. Elevated serum/plasma beta-2-m can be seen with decreased glomerular filtration rate/renal insufficiency. Elevated urine beta-2-m can be seen as a result of impaired proximal tubular reabsorption.

Reference Range

0 - 2 mg/L

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Collect specimen in SST tube.

Collection Offsite

Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.3 mL serum

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.