The Autism/ID Panel may be ordered as a single reflexive test (order code AUS). By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated. Each Tier and each assay in the panel may also be ordered individually. Tier 1 (AUS1) includes: Chromosomal Microarray Analysis (SNPM1)(http://www.pathology.med.umich.edu/handbook/?testID=4760), Fragile X Syndrome Mutation Detection (FRXFA)(http://www.pathology.med.umich.edu/handbook/?testID=427), and Prader-Willi / Angelman Syndrome by PCR (PWSMP)(http://www.pathology.med.umich.edu/handbook/?testID=4814), which may detect the underlying genetic cause in 17-24% of ASD/ID cases (Miller et al. 2010; Miles et al. Genet Med 13:278-294, 2011; Kelleher et al. Cell 135:401-406, 2008). If no mutations are detected in Tier 1, then Tier 2 will be performed. Tier 2 (AUS2) includes: MECP2 and PTEN full gene sequencing and deletion / duplication analyses. Tier 2 may detect the underlying genetic cause in 5-20% cases of ASD/ID (Miles et al. 2011; Butler et al. J Med Genet 42:318-321, 2005; Varga et al. Genet Med 11:111-117, 2009). If no mutations are detected in Tier 2, then Tier 3 will be performed. Tier 3 (AUS3) includes full gene sequencing of nine genes that are associated with ASD/ID: UBE3A, MBD5, NLGN3, NLGN4X, SHANK2, SHANK3, SLC9A6, TCF4, and CDKL5. Tier 3 may detect up to 10% of the ASD/ID genetic causes (Kelleher et al. 2008; Talkowski et al. Am J Hum Genet 89:551-563, 2011; Leblond et al. PLoS Genet 8:e1002521, 2012; Gauthier et al. Am J Med Genet B Neuropsychiatr Genet 150B:421-424, 2009; Moessner et al. AM J Hum Genet 81:1289-1297, 2007). By ordering this test the clinician acknowledges that informed consent has been obtained from the patient as required by applicable state or federal laws and the ordering clinician has authorization from the patient permitting MLabs to report the test results to the ordering clinician. Test includes medical geneticist interpretation of results billed as a separate additional charge. This test is not available without interpretation.