PERFORMING LABORATORY CHANGE

 

Matrix Metalloproteinase-7 (MMP-7)

Order Code:                  CMMP7

Fee Code:                     AB050 (CPT 83519)

New Fee Code:             pending (CPT 83520)

Reference Laboratory:   Cincinnati Children’s 11738598

New Reference Lab:      Children’s Medical Center of Dallas

 

Cincinnati Children's has discontinued the Matrix Metalloproteinase-7 (MMP-7) assay effective June 30, 2023. Requests for this test will be sent to Children’s Medical Center, Dallas, TX.  There will be no change to the order code.

 

Collection Instructions: Collect specimen in an SST or red top tube. Place on ice immediately after collection. Centrifuge, aliquot serum into a plastic vial and freeze within 2 hours of collection.

 

Reference Range:  3.6 – 10.5 ng/mL

 

MMP-7 level ≥ 18.2 ng/mL has 95% sensitivity and 65% specificity for diagnosis of biliary atresia, with negative predictive value of 97%.

 

Caution should be exercised in the interpretation of any assay for MMP-7, and the results should be considered in conjunction with the patient’s clinical condition. High MMP-7 have been detected in premature babies and young infants with cardiovascular and/ or multi-system disease. The final diagnosis of biliary atresia requires intraoperative cholangiography and the histological presence of obstruction of the extrahepatic bile duct. The normal values of MMP-7 in premature babies have not yet been established. Clinical correlation is particularly important in premature babies.